Strides in Science
AADR Strides in Science is a monthly feature highlighting an AADR member’s accomplishments and comments on how his/her involvement with AADR has been an important part of his/her career in research. If you would like to nominate a colleague to be featured, please send his/her name to firstname.lastname@example.org.
This month, AADR is featuring AADR Institutional Section Member the University of Michigan School of Dentistry in the Strides in Science. AADR interviewed Associate Dean Russell Taichman to learn more about the scientific advances the school is making.
Currently, the University of Michigan School of Dentistry is an AADR President’s Circle Level Institutional Section Member. They have been a member since 1999 and have exhibited at many IADR and AADR meetings, including the 2014 AADR/CADR Annual Meeting & Exhibition in Charlotte, N.C.
Last year, the University of Michigan School of Dentistry set a goal to raise $35 million during the University’s Victors for Michigan fundraising campaign. The School’s effort is part of a larger University goal to raise $4 billion, the largest fundraising effort in the history of public higher education, before the campaign ends in 2018.
The School’s $35 million goal includes the following objectives:
- Scholarship and Fellowship Support: $11.0 million;
- Clinical Facilities Support: $18.0 million;
- Curriculum Support: $1.0 million;
- Faculty Support: $1.5 million;
- Research Support: $1.5 million; and
- Discretionary Support: $2.0 million.
In 2012, the University announced the MCubed program, which is a two-year seed-funding program designed to empower interdisciplinary teams of University of Michigan faculty to pursue new initiatives with major societal impact. The program minimizes the time between idea conception and successful research results by providing immediate startup funds for novel, high-risk and transformative research projects. The funds are intended to generate data for groundbreaking, high-impact publications, or preliminary results for new, innovative research proposals. The program also includes high-visibility, campus-wide research symposia to showcase the resulting groundbreaking research. Taichman and 22 other School of Dentistry investigators are participating investigators in the 200 pilot projects funded through the MCubed program. More information may be found at www.mcubed.umich.edu.
University of Michigan faculty researcher Yvonne Kapila in her lab.
What is one of the main research goals of the School of Dentistry?
Research and discovery are integral to the School of Dentistry’s mission. The overarching goal is to facilitate clinical excellence by moving discoveries in the clinic to the bench top and back to the clinic. Working toward that goal, we have invested heavily in basic, clinical and translational research as well as educational and leadership research. Many of our faculty move across these platforms. One of our major efforts is to provide opportunities for all of our students to be involved in scholarship. In their first year, DDS students have a choice to get involved in three major scholarship venues. They can select a project in the research track, clinical-translational care track (health care delivery), and the leadership track. The expectation is that even at the earliest entry phase into the profession, these students are looking at their profession differently and the project they chose facilitates a deeper dive into the profession. This is our Pathway Program.
What is some of the research the School of Dentistry is producing?
The very best thing about the University of Michigan School of Dentistry is the people. We have many investigators engaged in very impressive science. Our excellent faculty and inspired students allow us to build on the strengths of our research enterprise, specifically in the areas of craniofacial and developmental biology; mineralized tissue and bone biology; oral and pharyngeal cancer; oral sensory pain neuroscience; oral infectious and immunologic diseases; and tissue engineering and regeneration. Projects are underway that involve the use of gene therapy to stop the progression of periodontal disease; tissue engineering approaches to repair head/neck/facial injuries; the mechanics of chewing and TMJ disorders; examining the oral health of women who are undergoing breast cancer therapy; and the regeneration of tissues, such as lips. A group of investigators are studying craniofacial development, genetics and infectious diseases, and many investigators are involved in cancer research. Important clinical investigations are being conducted on dental caries, restorative biology and quality of life issues. My research focus is on the role of osteoblasts in normal bone marrow function. It is exciting to be part of this incredible research enterprise.
How is the School of Dentistry encouraging students to pursue careers in dental research?
Matching students with mentors who have similar research interests is one of the ways we help students see how a career in oral health research can be rewarding. It’s exciting when students find research mentors who are willing to take them under their wing. Some students come into the dental school with a significant background in research and some come with none at all. I have a student in my lab who had no background in research, but a very keen interest. He was given an opportunity to do research and he enjoys it. We also support students who want to participate in an on campus year-out period to conduct basic or clinical research. Through the Intensive Clinical Research Training Program and the Medical Research Scholars Program, students may travel to the NIH-NIDCR for this training. We also have an Oral Health Sciences PhD Program. This Program is designed for exceptional students who aspire to a career in academic dentistry as a dental scientist. Training options include a dual degree in DDS/OHS PhD, Specialty MS/OHS PhD, and the PhD. Most of our graduates have gone on to academic careers with peer U.S. universities or international universities.
How do you prepare students to present their research at scientific meetings?
Once we match students with mentors, the students are given the opportunity to do an individualized research project that can range from basic science to clinical / translational research. Working with their research mentors, students who have a goal of presenting their work at IADR/AADR meetings are able to plan and do research that is appropriate for those meetings.
What are you telling students to encourage them to pursue careers in dental research?
I frequently say that it is the absolute best career choice you can make. You can pursue your dreams in science and dentistry, and there are relatively few barriers to make that happen. The doors that get opened are absolutely stunning. If you are passionate about dental research and you can secure the resources needed, you can do almost anything! I am very grateful that I made the choice to pursue dental research—even on the difficult days I’m still grateful for making this my path. I started out as a bench scientist and my work is now moving into clinical trials. I never thought that I would be engaged in those opportunities but this university setting has made that a reality. I’m excited for the next generation of scientists who will also contribute to the field.
David C. Johnsen, D.D.S., M.S., is dean and a professor at the University of Iowa, College of Dentistry and Dental Clinics, Department of Pediatric Dentistry. Johnsen received his D.D.S. degree from the University of Michigan in 1970 and his M.S. in pediatric dentistry from the University of Iowa in 1973. He became board certified in pediatric dentistry in 1978.
Johnsen served on the faculty of West Virginia University from 1974-1980, where he taught predoctoral pediatric dentistry. There, he received the Outstanding Teacher Award in 1976. In 1980 he joined Case Western Reserve University, where he continued teaching predoctoral pediatric dentistry. He remained on the faculty until 1995, serving as a department chair, intermittently as director of the residency program, and as interim dean in 1993. From there he moved to the University of Iowa, where he has been the dean of the College of Dentistry since 1995.
His university service at the University of Iowa has included chairing the search committee for the CEO of the University of Iowa Hospitals and Clinics in 2002; being co-convener of the Health Sciences Policy Council from 2003-04; co-chairing the University Task Force on Clinical and Translational Research in 2005-06; being the chair of the nursing dean search in 2006; and serving as chair of the university presidential search in 2007.
Johnsen’s research has focused on innervation of teeth as an indicator of capacity to transmit pain sensory impulses and also on caries patterns in preschoolers. The latter area included demonstration projects and consulting at the national level in the Women and Infant Clinics (WIC) and the Head Start programs. He has also published on a variety of clinical and educational topics.
Johnsen has been an active AADR member since 1973 and has served as the chair of the AADR Government Affairs Committee since 2011.
How did you first learn about AADR?
I first learned about AADR while I was a student at the University of Michigan, through my dental histology professor Jim Avery, who later became an IADR president (1974-75). After that I did pediatrics at the University of Iowa where another future IADR president, Stephen Wei (1993-94), was one of my professors. From early on I knew about the importance of IADR and AADR because those two mentors were members and they explained to me why I should be involved. At the encouragement of Jim Avery, I made my first presentation at an IADR meeting in 1970 and I’ve attended nearly every meeting since then. Thanks to my mentors I was indoctrinated into IADR/AADR early on in my career!
Describe your first time presenting at an IADR/AADR meeting.
I was a student the first time I presented at a meeting. I’m not sure how many students presented from my school that year but it was with the coaching of my mentor Jim Avery that I had the ability to present my research. He showed me how to structure my presentation—we practiced it together and he would ask questions to allow me to rehearse my answers. I still recall the experience of presenting my research at the meeting and getting questions from famous researchers in the room. I was honored that these famous researchers I had read about were there and they liked my presentation. It was definitely a valuable experience and one I’ll never forget.
What do you find to be the most valuable benefit of AADR membership?
One of the most valuable benefits of my AADR membership is being part of the AADR network, in addition to the advocacy the Association provides. AADR, with IADR, is the touchstone for dental research, and AADR is the place I turn for gathering with other dental researchers and people in the field. When I was just becoming involved in AADR and doing my research in Jim Avery’s lab, I really became hooked on research when he introduced me to the AADR environment. It wasn’t just the intellectual stimulation that I enjoyed but also the IADR/AADR members from all over the world who would visit the lab. I realized early on that I had never been around a group like that and I found them really enthralling. I’m proud to be part of this group that I found so enthralling as a junior researcher. I’m also fortunate that my institution supported my efforts to be involved in AADR because there isn’t a better place for meeting with other researchers and learning about dental research.
What is one of the best ways for other AADR members to become more involved in the Association’s advocacy efforts?
When I’m in DC I always stop in Senator Tom Harkin’s office to meet with him. There’s value in meeting with your representatives in person. However, if you’re not able to meet with them, send them a letter. It’s critical that we explain to them the importance of biomedical research and we need to explain how our research impacts the health of the public. It’s up to us to share our stories with representatives and policymakers because no one else can. Years ago, when then NIH Director Francis Collins visited the NIDCR Advisory Group, I asked him how we could help. Without hesitation he said “Get your elected officials into your institutions to see the great work you are doing!” A year later at the NIDCR Advisory Group meeting when we were asked how many of us tried to get our elected officials to visit our institutions, only a few hands went up. As a dean I think that it’s important to get more dental deans involved collectively to get dental research supported. I think we’re going to have a real battle to maintain the level of support that we’ve had. Higher education has become a lot tighter and we do have to subsidize research. To keep that going, I think it’s going to take the grassroots of the dental deans, too.
He earned his B.V.Sc. in veterinary medicine and surgery from Madras University, Chennia, India, in 1971; his S.C.C. in advanced statistics from the Institute of Agricultural Research Statistics, New Delhi, India, in 1975; and his M.Sc. in medical microbiology from All India Institute of Medical Sciences, New Delhi, in 1979. Additionally, he was a post-doc fellow at the National Jewish Center for Immunology and Respiratory Medicine, Denver and at the University of Texas at San Antonio Health and Science Center, where he worked on a National Institutes of Health-National Institute of Dental and Craniofacial Research project under his research mentors Jeffrey Ebersole and Stanley Holt.
Currently Lakshmyya is conducting several research studies, including a clinical study on the association between periodontal disease and cardiovascular disease, periodontal pathogens and induction of periodontal disease and atherosclerosis in ApoE-/- mouse model, caries pathogenStreptococcus mutans role in atherosclerosis in ApoE-/- mouse model, polymicrobial periodontal disease and localization of periodontal pathogens in periodontium, the association between periodontal pathogens and rheumatoid arthritis in DBA1 and B10 RIII mouse model, and the association between periodontal pathogens and Alzheimer’s disease in humans and animal model.
Recently, he and a team of researchers released findings about how gum disease can lead to heart disease, which could change the way heart disease is diagnosed and treated. Funded by the NIH-NIDCR, that study is part of a larger one on the effects of gum disease on atherosclerotic vascular disease. Similarly, last year he and a team of UK researchers released findings on the potential link between gum disease and Alzheimer’s disease.
Lakshmyya has been an AADR member since 1990. As an active member, he has served as an AADR Section officer, and has been a member of the AADR Council and AADR Fellowships Committee. Additionally, he has served as a reviewer for the IADR/AADR Journal of Dental Research.
What motivated you to join AADR?
I joined AADR at the encouragement of my mentors when I was a post-doc fellow. At the time I was working on an NIH-NIDCR project in the laboratory of Dr. Jeffrey Ebersole and Dr. Stanley Holt. My mentors explained to me the benefits of AADR membership and why I should attend the meetings. Since then, I have attended the meetings and been an active member in the Association.
What do you find to be the most valuable benefit of AADR membership?
I have found the access to information and to dentists and other researchers to be one of the most valuable benefits of my AADR membership. Being an AADR member enables me to attend the Annual Meetings and present my research, but it also gives me a platform to network with others in the field. I am not a dentist—I rely on my AADR membership to help me meet dentists and researchers in other specialties because that is of interest to me and my research. Being a member of AADR and especially attending the Annual Meetings gives me exposure to all the people I need to meet in order to help further my research. Attending the meetings is a significant resource for a dental researcher and it’s helpful that AADR offers this experience at a discounted rate for members.
How important has AADR been in your career?
AADR is really the bread and butter that has helped build my career and I am fortunate for the opportunities that my membership has provided to me. I am also grateful to my mentors Dr. Jeffrey Ebersole and Dr. Stanley Holt for introducing me to AADR, I am very fortunate to have them as my mentors. One of the biggest gifts of being part of AADR is being able to collaborate with others in the field of dental research. Having that opportunity available has made a positive impact on my career, and I encourage others who are not members to join and be part of this Association so that they, too, may partake in the membership experience.
What role does cross-collaboration play in obtaining your research findings?
Cross-collaboration plays a big role in my research and being part of AADR has helped me identify future research collaborators in different disciplines. I have been collaborating with other universities and faculty to do various research projects. In order to have more access to information and to do better research, it’s important to collaborate with others globally.
What’s a message you want to give to future dental researchers?
My advice is really to mentors and faculty but it benefits future dental researchers. I encourage faculty members to mentor students and support them in their growth. I am fortunate that the University of Florida is able to send some of my students and junior researchers to the AADR Annual Meetings so that they have exposure to the specialty science that’s presented at the meeting. We all should encourage more students to attend these meetings and, if we’re not able to help off-set the cost of meeting registration, help them find funding. Grad students and post-docs will benefit enormously from the meetings because they will be the future dental researchers and the future academicians.
AADR Strides in Science, September 2013-July 2014
AADR Strides in Science, November 2012-August 2013
AADR Strides in Science, January 2012-September 2012
AADR Strides in Science, March 2011-December 2011
AADR Strides in Science, June 2010-February 2011
AADR Strides in Science, October 2009-May 2010
AADR Strides in Science, February 2009-September 2009
AADR Strides in Science, June 2008-January 2009